Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture
Joint Authors
Liang, Qian-Qian
Ding, Dao-Fang
Xi, Zhi-Jie
Chen, Yan
Li, Chen-Guang
Liu, Shu-Fen
Lu, Sheng
Zhao, Yong-Jian
Shi, Qi
Wang, Yong-Jun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc.
Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes.
Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration.
To determine the effect of ligustrazine on disc degeneration, we applied a rat model.
The intervertebral disc degeneration of the rats was induced by prolonged upright posture.
We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1β, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression.
In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease.
American Psychological Association (APA)
Liang, Qian-Qian& Ding, Dao-Fang& Xi, Zhi-Jie& Chen, Yan& Li, Chen-Guang& Liu, Shu-Fen…[et al.]. 2014. Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018590
Modern Language Association (MLA)
Liang, Qian-Qian…[et al.]. Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018590
American Medical Association (AMA)
Liang, Qian-Qian& Ding, Dao-Fang& Xi, Zhi-Jie& Chen, Yan& Li, Chen-Guang& Liu, Shu-Fen…[et al.]. Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018590