Sodium Hydrosulfide Relieves Neuropathic Pain in Chronic Constriction Injured Rats
Joint Authors
Lin, Jian-qing
Luo, Hui-qin
Lin, Cai-zhu
Chen, Jin-zhuan
Lin, Xian-zhong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aberrant neuronal activity in injured peripheral nerves is believed to be an important factor in the development of neuropathic pain (NPP).
Channel protein pCREB of that activity has been shown to mitigate the onset of associated molecular events in the nervous system, and sodium hydrosulfide (NaHS) could inhibit the expression of pCREB.
However, whether NaHS could relieve the pain, it needs further experimental research.
Furthermore, the clinical potential that NaHS was used to relieve pain was limited so it would be required.
To address these issues, the rats of sciatic nerve chronic constriction injury (CCI) were given intraperitoneal injection of NaHS containing hydrogen sulfide (H2S).
The experimental results showed that NaHS inhibited the reduction of paw withdrawal thermal latency (PWTL), mechanical withdrawal threshold (MWT), and the level of pCREB in CCI rats in a dose-dependent manner and they were greatly decreased in NaHSM group (P < 0.05).
NaHS alleviates chronic neuropathic pain by inhibiting expression of pCREB in the spinal cord of Sprague-Dawley rats.
American Psychological Association (APA)
Lin, Jian-qing& Luo, Hui-qin& Lin, Cai-zhu& Chen, Jin-zhuan& Lin, Xian-zhong. 2014. Sodium Hydrosulfide Relieves Neuropathic Pain in Chronic Constriction Injured Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018596
Modern Language Association (MLA)
Lin, Jian-qing…[et al.]. Sodium Hydrosulfide Relieves Neuropathic Pain in Chronic Constriction Injured Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1018596
American Medical Association (AMA)
Lin, Jian-qing& Luo, Hui-qin& Lin, Cai-zhu& Chen, Jin-zhuan& Lin, Xian-zhong. Sodium Hydrosulfide Relieves Neuropathic Pain in Chronic Constriction Injured Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018596