Ginsenosides Rg1 from Panax ginseng: A Potential Therapy for Acute Liver Failure Patients?
Joint Authors
Zhao, Jinqiu
Shi, Zhengyu
Liu, Shu
Li, Jiajun
Huang, Wenxiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acute liver failure (ALF) is a rapidly progressing critical illness with a high mortality rate.
Circulating inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), play a significant role in the pathophysiology of ALF through promoting hepatocellular apoptosis.
Ginsenoside Rg1, the primary active ingredient in Panax ginseng (also termed Asian or Korean ginseng), has been reported to inhibit TNF-α production and has been shown to significantly attenuate liver fibrosis development.
Here, we assessed ginsenoside Rg1’s potential as a therapy for ALF by investigating the effect of ginsenoside Rg1 treatment on circulating inflammatory markers, hepatocellular apoptosis, and relevant apoptotic signaling pathways in a well-established murine ALF model.
We found that ginsenoside Rg1 significantly reduces liver damage in a murine ALF model through inhibiting TNF-α-induced, caspase-dependent hepatocellular apoptosis.
These results support the further investigation of ginsenoside Rg1 as a therapeutic candidate for ALF.
American Psychological Association (APA)
Zhao, Jinqiu& Shi, Zhengyu& Liu, Shu& Li, Jiajun& Huang, Wenxiang. 2014. Ginsenosides Rg1 from Panax ginseng: A Potential Therapy for Acute Liver Failure Patients?. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018617
Modern Language Association (MLA)
Zhao, Jinqiu…[et al.]. Ginsenosides Rg1 from Panax ginseng: A Potential Therapy for Acute Liver Failure Patients?. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018617
American Medical Association (AMA)
Zhao, Jinqiu& Shi, Zhengyu& Liu, Shu& Li, Jiajun& Huang, Wenxiang. Ginsenosides Rg1 from Panax ginseng: A Potential Therapy for Acute Liver Failure Patients?. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018617