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Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson’s Disease: Involvement of the Dopamine System
Joint Authors
Liu, Jia
Gao, Jinlong
Tu, Shaoang
Xu, Shasha
Liu, Ying
Shang, Weihu
Gu, Chenxin
Huang, Yiyun
Han, Mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Jitai tablet (JTT) is a traditional Chinese medicine used to treat neuropsychiatric disorders.
We previously demonstrated that JTT treatment led to increased level of dopamine transporter (DAT) in the striatum, thus indicating that JTT might have therapeutic potential for Parkinson’s disease (PD), which is characterized by dysregulated dopamine (DA) transmission and decreased striatal DAT expression.
The aim of this study was to investigate the neuroprotective effect of JTT on MPTP-induced PD mice.
Using locomotor activity test and rotarod test, we evaluated the effects of JTT (0.50, 0.15, or 0.05 g/kg) on MPTP-induced behavioral impairments.
Tyrosine hydroxylase TH-positive neurons in the substantia nigra and DAT and dopamine D2 receptor (D2R) levels in the striatum were detected by immunohistochemical staining and/or autoradiography.
Levels of DA and its metabolites were determined by HPLC.
In MPTP-treated mice, behavioral impairments were alleviated by JTT treatment.
Moreover, JTT protected against impairment of TH-positive neurons and attenuated the MPTP-induced decreases in DAT and D2R.
Finally, high dose of JTT (0.50 g/kg) inhibited the MPTP-induced increase in DA metabolism rate.
Taken together, results from our present study provide evidence that JTT offers neuroprotective effects against the neurotoxicity of MPTP and thus might be a potential treatment for PD.
American Psychological Association (APA)
Liu, Jia& Gao, Jinlong& Tu, Shaoang& Xu, Shasha& Liu, Ying& Shang, Weihu…[et al.]. 2014. Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson’s Disease: Involvement of the Dopamine System. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018619
Modern Language Association (MLA)
Liu, Jia…[et al.]. Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson’s Disease: Involvement of the Dopamine System. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018619
American Medical Association (AMA)
Liu, Jia& Gao, Jinlong& Tu, Shaoang& Xu, Shasha& Liu, Ying& Shang, Weihu…[et al.]. Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson’s Disease: Involvement of the Dopamine System. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018619