Effect of Huanglian Jiedu Decoction on Thoracic Aorta Gene Expression in Spontaneous Hypertensive Rats
Joint Authors
Yue, Gui-Hua
Zhuo, Shao-Yuan
Xia, Meng
Zhang, Zhuo
Gao, Yi-Wen
Luo, Yuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hypertension is one of the most common cardiovascular disorders with high mortality.
Here we explored the antihypertension effects of Huanglian Jiedu Decoction (HJD) on thoracic aorta gene expression in spontaneous hypertensive rats.
Methods.
A rat model of spontaneous hypertension was used.
The gene change profile of thoracic aorta after JHD treatment was assessed by GeneChip(GC) analysis using the Agilent Whole Rat Genome Oligo Microarray.
Results.
Hypertension induced 441 genes upregulated and 417 genes downregulated compared with the normal control group.
Treatment of HJD resulted in 76 genes downregulated and 20 genes upregulated.
GC data analysis showed that the majority of change genes were involved in immune system process, developmental process, and cell death.
Conclusion.
Hypertension altered expression of many genes that regulate various biological functions.
HJD significantly reduced hypertension and altered the gene expression profiles of SHR rats.
These changing genes were involved in many cellular functions such as regulating smooth muscle contraction, Ca(2+) homeostasis, and NO pathway.
This study provides the potential novel insights into hypertension and antihypertension effects of HJD.
American Psychological Association (APA)
Yue, Gui-Hua& Zhuo, Shao-Yuan& Xia, Meng& Zhang, Zhuo& Gao, Yi-Wen& Luo, Yuan. 2014. Effect of Huanglian Jiedu Decoction on Thoracic Aorta Gene Expression in Spontaneous Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018645
Modern Language Association (MLA)
Yue, Gui-Hua…[et al.]. Effect of Huanglian Jiedu Decoction on Thoracic Aorta Gene Expression in Spontaneous Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018645
American Medical Association (AMA)
Yue, Gui-Hua& Zhuo, Shao-Yuan& Xia, Meng& Zhang, Zhuo& Gao, Yi-Wen& Luo, Yuan. Effect of Huanglian Jiedu Decoction on Thoracic Aorta Gene Expression in Spontaneous Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018645