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Effect of Poria cocos on Puromycin Aminonucleoside-Induced Nephrotic Syndrome in Rats
Joint Authors
Kang, Dae Gill
Lee, Yun Jung
Lee, So Min
Yoon, Jung Joo
Lee, Ho Sub
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Nephrotic syndrome is associated with altered renal handling of water and sodium and changes in the levels of aquaporins (AQPs) and epithelial Na channels (ENaCs).
The dried sclerotia of Poria cocos Wolf (WPC) have been used for treating chronic edema and nephrosis.
We evaluated the effects of WPC on puromycin aminonucleoside- (PAN-) induced renal functional derangement and altered renal AQP2 and ENaC expression.
In the nephrotic syndrome rat model, animals were injected with 75 mg/kg PAN and then treated with Losartan (30 mg·kg−1·day−1) or WPC (200 mg·kg−1·day−1) for 7 days.
In the WPC group, proteinuria and ascites improved significantly.
Plasma levels of triglyceride, total cholesterol, and low-density lipoprotein- (LDL-) cholesterol reduced significantly in the WPC group.
In addition, the WPC group exhibited attenuation of the PAN-induced increase in AQP2 and ENaC α/β subunit protein and mRNA levels.
WPC suppressed significantly PAN-induced organic osmolyte regulators, reducing serum- and glucocorticoid-inducible protein kinase (Sgk1) and sodium-myo-inositol cotransporter (SMIT) mRNA expression.
Our results show that WPC improves nephrotic syndrome, including proteinuria and ascites, through inhibition of AQP2 and ENaC expression.
Therefore, WPC influences body-fluid regulation via inhibition of water and sodium channels, thereby, improving renal disorders such as edema or nephrosis.
American Psychological Association (APA)
Lee, So Min& Lee, Yun Jung& Yoon, Jung Joo& Kang, Dae Gill& Lee, Ho Sub. 2014. Effect of Poria cocos on Puromycin Aminonucleoside-Induced Nephrotic Syndrome in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018667
Modern Language Association (MLA)
Lee, So Min…[et al.]. Effect of Poria cocos on Puromycin Aminonucleoside-Induced Nephrotic Syndrome in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1018667
American Medical Association (AMA)
Lee, So Min& Lee, Yun Jung& Yoon, Jung Joo& Kang, Dae Gill& Lee, Ho Sub. Effect of Poria cocos on Puromycin Aminonucleoside-Induced Nephrotic Syndrome in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018667