A friendly environment approach for determination of paracetamol

Abstract EN

This paper involves a determination of paracetamol using less environment harmful reagent; the hydroxy analog of the pharmaceutical naproxen replaces the chemical reagent in which it is used as a coupling agent for the diazotized p-aminophenol (the hydrolysis product of paracetamol).The paper offers a determination of an analgesic paracetamol in the presence of high content of another analgesic.

Paracetamol azo-dye formed shows the higher absorption peak at 500 nm.

Absorbanceconcentration relation is liner over the range from 10 to 650 µg/20ml, (i.e.

0.5-32.5 ppm) with a good sensitivity (molar absorptivity 1.2x104 l.mol-1 .cm-1 ) ; good precision (RSD better than ±0.275%) and high accuracy (relative error less than + 0.77%), Sandell's sensitivity index is 0.0124µg.cm-2 , the calculated limit of detection (LOD) is 0.0030 µg/ml and the evaluated limit of quantitation (LOQ) is 0.0101 µg/ml.

The application of the method exhibits a successful results for determination of paracetamol in dosage forms and it's already applied for the determination of paracetamol in presence of naproxen.