Effect of Da-Cheng-Qi Decoction on the Repair of the Injured Enteric Nerve-Interstitial Cells of Cajal-Smooth Muscle Cells Network in Multiple Organ Dysfunction Syndrome
Joint Authors
Liu, Mu-Cang
Xie, Ming-Zheng
Ma, Bin
Qi, Qing-Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Wistar rats were randomly divided into control group, multiple organ dysfunction syndrome (MODS) group, and Da-Cheng-Qi decoction (DCQD) group.
The network of enteric nerves-interstitial cells of Cajal- (ICC-) smooth muscle cells (SMC) in small intestine was observed using confocal laser scanning microscopy and transmission electron microscopy.
The results showed that the numbers of cholinergic/nitriergic nerves, and the deep muscular plexus of ICC (ICC-DMP) and connexin43 (Cx43) in small intestine with MODS were significantly decreased.
The network integrity of enteric nerves-ICC-SMC was disrupted.
The ultrastructures of ICC-DMP, enteric nerves, and SMC were severely damaged.
After treatment with DCQD, the damages were repaired and the network integrity of enteric nerves ICC-SMC was significantly recovered.
In conclusion, the pathogenesis of gastrointestinal motility dysfunction in MODS in part may be due to the damages to enteric nerves-ICC-SMC network and gap junctions.
The therapeutic mechanism of DCQD in part may be that it could repair the damages and maintain the integrity of enteric nerves ICC-SMC network.
American Psychological Association (APA)
Liu, Mu-Cang& Xie, Ming-Zheng& Ma, Bin& Qi, Qing-Hui. 2014. Effect of Da-Cheng-Qi Decoction on the Repair of the Injured Enteric Nerve-Interstitial Cells of Cajal-Smooth Muscle Cells Network in Multiple Organ Dysfunction Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018720
Modern Language Association (MLA)
Liu, Mu-Cang…[et al.]. Effect of Da-Cheng-Qi Decoction on the Repair of the Injured Enteric Nerve-Interstitial Cells of Cajal-Smooth Muscle Cells Network in Multiple Organ Dysfunction Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1018720
American Medical Association (AMA)
Liu, Mu-Cang& Xie, Ming-Zheng& Ma, Bin& Qi, Qing-Hui. Effect of Da-Cheng-Qi Decoction on the Repair of the Injured Enteric Nerve-Interstitial Cells of Cajal-Smooth Muscle Cells Network in Multiple Organ Dysfunction Syndrome. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018720
