Extracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice
Joint Authors
Zhang, Ke
Ma, Xu
He, Wenjun
Li, Haixia
Han, Shuyan
Jiang, Yong
Wu, Hounan
Han, Li
Ohno, Tomohiro
Uotsu, Nobuo
Yamaguchi, Kohji
Ma, Zhizhong
Tu, Pengfei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The senescence accelerated mouse prone 8 substrain (SAM-P8), widely accepted as an animal model for studying aging and antiaging drugs, was used to examine the effects of dietary supplementation with extracts of Cistanche deserticola (ECD) which has been used extensively in traditional Chinese medicine because of its perceived ability to promote immune function in the elderly.
Eight-month-old male SAM-P8 mice were treated with ECD by daily oral administrations for 4 weeks.
The results showed that dietary supplementation of 150 mg/kg and 450 mg/kg of ECD could extend the life span measured by Kaplan-Meier survival analysis in dose-dependent manner.
Dietary supplementation of SAM-P8 mice for 4 weeks with 100, 500, and 2500 mg/kg of ECD was shown to result in significant increases in both naive T and natural killer cells in blood and spleen cell populations.
In contrast, peripheral memory T cells and proinflammatory cytokine, IL-6 in serum, were substantially decreased in the mice that ingested 100 and 500 mg/kg of ECD daily.
Additionally, Sca-1 positive cells, the recognized progenitors of peripheral naive T cells, were restored in parallel.
Our results provide clear experimental support for long standing clinical observational studies showing that Cistanche deserticola possesses significant effects in extending life span and suggest this is achieved by antagonizing immunosenescence.
American Psychological Association (APA)
Zhang, Ke& Ma, Xu& He, Wenjun& Li, Haixia& Han, Shuyan& Jiang, Yong…[et al.]. 2014. Extracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1018724
Modern Language Association (MLA)
Zhang, Ke…[et al.]. Extracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1018724
American Medical Association (AMA)
Zhang, Ke& Ma, Xu& He, Wenjun& Li, Haixia& Han, Shuyan& Jiang, Yong…[et al.]. Extracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1018724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018724