Neurotrophic Signaling Factors in Brain IschemiaReperfusion Rats: Differential Modulation Pattern between Single-Time and Multiple Electroacupuncture Stimulation
Joint Authors
Guo, Jingchun
Wang, Changpeng
Yang, Fan
Liu, Xiaoyan
Liu, Ming
Zheng, Yun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Electroacupuncture (EA) treatment has been widely used for stroke-like disorders in traditional Chinese medicine.
However, the underlying mechanisms remain unclear.
Our previous studies showed that single-time EA stimulation at “Baihui” (GV 20) and “Shuigou” (GV 26) after the onset of ischemia can protect the brain against ischemic injury in rats with middle cerebral artery occlusion (MCAO).
Here, we further investigated the differential effects between multiple EA and single-time EA stimulation on ischemic injury.
In the present study, we found that both single-time EA and multiple EA stimulation significantly reduced MCAO-induced ischemic infarction, while only multiple EA attenuated sensorimotor dysfunctions.
Also, with PCR array screening and ingenuity gene analysis, we revealed that multiple EA and single-time EA stimulation could differentially induce expression changes in neurotrophic signaling related genes.
Meanwhile, with western blotting, we demonstrated that the level of glia maturation factor β (GMFβ) increased in the early stage (day 1) of reperfusion, and this upregulation was suppressed only by single-time EA stimulation.
These findings suggest that the short-term effect of single-time EA stimulation differs from the cumulative effect of multiple EA, which possibly depends on their differential modulation on neurotrophic signaling molecules expression.
American Psychological Association (APA)
Wang, Changpeng& Yang, Fan& Liu, Xiaoyan& Liu, Ming& Zheng, Yun& Guo, Jingchun. 2014. Neurotrophic Signaling Factors in Brain IschemiaReperfusion Rats: Differential Modulation Pattern between Single-Time and Multiple Electroacupuncture Stimulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1018751
Modern Language Association (MLA)
Wang, Changpeng…[et al.]. Neurotrophic Signaling Factors in Brain IschemiaReperfusion Rats: Differential Modulation Pattern between Single-Time and Multiple Electroacupuncture Stimulation. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1018751
American Medical Association (AMA)
Wang, Changpeng& Yang, Fan& Liu, Xiaoyan& Liu, Ming& Zheng, Yun& Guo, Jingchun. Neurotrophic Signaling Factors in Brain IschemiaReperfusion Rats: Differential Modulation Pattern between Single-Time and Multiple Electroacupuncture Stimulation. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1018751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018751