Antiatopic Dermatitis Effect of Artemisia iwayomogi in Dust Mice Extract-Sensitized NcNga Mice
Joint Authors
Shin, Hyeun-Kyoo
Seo, Chang-Seob
Lim, Hye-Sun
Lee, Hoyoung
Lee, Jun Kyoung
Lee, Mi-Young
Ha, Hyekyung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
Artemisia iwayomogi (AI) has been used for fever reduction, diuresis, and hepatoprotection in Korea.
The present study was performed to evaluate the anti-inflammatory and antiatopic dermatitis effects of AI using both in vitro and in vivo systems.
Methods.
The compositions in AI were analyzed by HPLC.
To determine the anti-inflammatory effects of AI, the production of nitric oxide (NO) was measured in lipopolysaccharide treated RAW264.7 cells.
Histamine levels were assayed to evaluate the antiallergic effects on MC/9 cells stimulated with phorbol-12 myristate 13-acetate and A23187.
Finally, AI (10 mg/mouse/day) was topically applied onto the backs and ears of Dermatophagoides farinae-sensitized Nc/Nga mice for four weeks.
Results.
Isochlorogenic acid A (20.63 ± 0.26 mg/g), chlorogenic acid (9.04 ± 0.08 mg/g), and scopoletin (8.23 ± 0.01 mg/g) were among the major components of AI.
AI inhibited the NO and histamine productions in RAW264.7 and MC/9 cells, respectively.
In the mice, the topical application of AI reduced the dermatitis scores in the dorsal skin and ears and reduced the plasma levels of IgE.
Conclusions.
These results suggest that AI might be explored as a potential therapeutic agent to treat AD, and that the analytic method using HPLC will facilitate the development of quality control for AI.
American Psychological Association (APA)
Ha, Hyekyung& Lee, Hoyoung& Seo, Chang-Seob& Lim, Hye-Sun& Lee, Mi-Young& Lee, Jun Kyoung…[et al.]. 2014. Antiatopic Dermatitis Effect of Artemisia iwayomogi in Dust Mice Extract-Sensitized NcNga Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018861
Modern Language Association (MLA)
Ha, Hyekyung…[et al.]. Antiatopic Dermatitis Effect of Artemisia iwayomogi in Dust Mice Extract-Sensitized NcNga Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018861
American Medical Association (AMA)
Ha, Hyekyung& Lee, Hoyoung& Seo, Chang-Seob& Lim, Hye-Sun& Lee, Mi-Young& Lee, Jun Kyoung…[et al.]. Antiatopic Dermatitis Effect of Artemisia iwayomogi in Dust Mice Extract-Sensitized NcNga Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018861