Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats
Joint Authors
Ji, Weifeng
Huang, Haiying
Chao, Ji
Lu, Wuchao
Guo, Jian-you
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present investigation examined the neuroprotective effect of Agaricus brasiliensis (AbS) against STZ-induced diabetic neuropathic pain in laboratory rats.
STZ-induced diabetic rats were administered orally with AbS.
Body weight, serum glucose, and behavioral parameters were measured before and at the end of the experiment to see the effect of AbS on these parameters.
After 6 weeks of treatments, all animals were sacrificed to study various biochemical parameters.
Treatment with AbS 80 mg/kg in diabetic animals showed significant increase in body weight, pain threshold, and paw withdrawal threshold and significant decrease in serum glucose, LPO and NO level, Na-K-ATPase level, and TNF-α and IL-1β level as compared to vehicle treated diabetic animals in dose and time dependent manner.
AbS can offer pain relief in PDN.
This may be of potential benefit in clinical practice for the management of diabetic neuropathy.
American Psychological Association (APA)
Ji, Weifeng& Huang, Haiying& Chao, Ji& Lu, Wuchao& Guo, Jian-you. 2014. Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018864
Modern Language Association (MLA)
Ji, Weifeng…[et al.]. Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1018864
American Medical Association (AMA)
Ji, Weifeng& Huang, Haiying& Chao, Ji& Lu, Wuchao& Guo, Jian-you. Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018864