Protein Fractions from Korean Mistletoe (Viscum Album coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells
Joint Authors
Kim, Jong-Bae
Kim, Ki-Wook
Yang, Seung-Hoon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mistletoe (Viscum Album coloratum) has been known as a medicinal plant in European and Asian countries.
Recent data show that biological activity of mistletoe alleviates hypertension, heart disease, renal failure, and cancer development.
In this study, we report the antidiabetic effect of Korean mistletoe extract (KME).
KME treatments enhanced the insulin secretion from the pancreatic β-cell without any effects of cytotoxicity.
PDX-1 and beta2/neuroD known as transcription factors that regulate the expression of insulin gene were upregulated by treatment of the KME protein fractions isolated by ion-exchange chromatography after ammonium sulfate precipitation.
Furthermore, these KME protein fractions significantly lowered the blood glucose level and the volume of drinking water in alloxan induced hyperglycemic mice.
Taken together with the findings, it provides new insight that KME might be served as a useful source for the development of medicinal reagent to reduce blood glucose level of type I diabetic patients.
American Psychological Association (APA)
Kim, Ki-Wook& Yang, Seung-Hoon& Kim, Jong-Bae. 2014. Protein Fractions from Korean Mistletoe (Viscum Album coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018907
Modern Language Association (MLA)
Kim, Ki-Wook…[et al.]. Protein Fractions from Korean Mistletoe (Viscum Album coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018907
American Medical Association (AMA)
Kim, Ki-Wook& Yang, Seung-Hoon& Kim, Jong-Bae. Protein Fractions from Korean Mistletoe (Viscum Album coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018907