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Effect of Isopropanolic Cimicifuga racemosa Extract on Uterine Fibroids in Comparison with Tibolone among Patients of a Recent Randomized, Double Blind, Parallel-Controlled Study in Chinese Women with Menopausal Symptoms
Joint Authors
Xi, Sisi
Liske, Eckehard
Wang, Shuyu
Liu, Jianli
Zhang, Zhonglan
Geng, Li
Hu, Lina
Jiao, Chunfeng
Zheng, Shurong
Zepelin, Hans-Heinrich Henneicke-von
Bai, Wenpei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Effect of isopropanolic Cimicifuga racemosa extract (iCR) on uterine fibroid size compared with tibolone.
Method.
The randomized, double-blind, controlled study in China enrolled 244 patients aged 40–60 years with menopausal symptoms (Kupperman Menopause Index ≥ 15).
The participants were treated with either iCR of 40 mg crude drug/day ( N = 122 ) or tibolone 2.5 mg/day ( N = 122 ) orally for 3 months in 2004.
Now, we investigated the subset of all women ( N = 62 ) with at least one uterine fibroid at onset of treatment for the effect of iCR (N = 34) on fibroid size compared with tibolone ( N = 28 ) by transvaginal ultrasonography.
Results.
The median myoma volume decreased upon iCR by as much as −30% ( P = 0.016 ) but increased upon tibolone by + 4.7 % .
The percentage of volume change, mean diameter change and geometric mean diameter change of the iCR group compared to tibolone were statistically significant ( P = 0.016 , 0.021, 0.016 respectively).
Conclusion.
Our results suggest that iCR (Remifemin) is a valid herbal medicinal product in patients with uterine myomas as it provides adequate relief from menopausal symptoms and inhibits growth of the myomas in contrast to tibolone.
American Psychological Association (APA)
Xi, Sisi& Liske, Eckehard& Wang, Shuyu& Liu, Jianli& Zhang, Zhonglan& Geng, Li…[et al.]. 2014. Effect of Isopropanolic Cimicifuga racemosa Extract on Uterine Fibroids in Comparison with Tibolone among Patients of a Recent Randomized, Double Blind, Parallel-Controlled Study in Chinese Women with Menopausal Symptoms. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018950
Modern Language Association (MLA)
Xi, Sisi…[et al.]. Effect of Isopropanolic Cimicifuga racemosa Extract on Uterine Fibroids in Comparison with Tibolone among Patients of a Recent Randomized, Double Blind, Parallel-Controlled Study in Chinese Women with Menopausal Symptoms. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1018950
American Medical Association (AMA)
Xi, Sisi& Liske, Eckehard& Wang, Shuyu& Liu, Jianli& Zhang, Zhonglan& Geng, Li…[et al.]. Effect of Isopropanolic Cimicifuga racemosa Extract on Uterine Fibroids in Comparison with Tibolone among Patients of a Recent Randomized, Double Blind, Parallel-Controlled Study in Chinese Women with Menopausal Symptoms. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018950