Preliminary Study of Quercetin Affecting the Hypothalamic-Pituitary-Gonadal Axis on Rat Endometriosis Model
Joint Authors
Cao, Yang
Zhuang, Meng-fei
Yang, Ying
Xie, Shu-wu
Cui, Jin-gang
Cao, Lin
Zhang, Ting-ting
Zhu, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In this study, the endometriosis rats model was randomly divided into 6 groups: model control group, ovariectomized group, Gestrinone group, and quercetin high/medium/low dose group.
Rats were killed after 3 weeks of administration.
The expression levels of serum FSH and LH were detected by ELISA.
The localizations and quantities of ERα, ERβ, and PR were detected by immunohistochemistry and western blot.
The results showed that the mechanism of quercetin inhibiting the growth of ectopic endometrium on rat endometriosis model may be through the decreasing of serum FSH and LH levels and then reducing local estrogen content to make the ectopic endometrium atrophy.
Quercetin can decrease the expression of ERα, ERβ, and PR in hypothalamus, pituitary, and endometrium, thereby inhibiting estrogen and progesterone binding to their receptors to play the role of antiestrogen and progesterone.
American Psychological Association (APA)
Cao, Yang& Zhuang, Meng-fei& Yang, Ying& Xie, Shu-wu& Cui, Jin-gang& Cao, Lin…[et al.]. 2014. Preliminary Study of Quercetin Affecting the Hypothalamic-Pituitary-Gonadal Axis on Rat Endometriosis Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1019036
Modern Language Association (MLA)
Cao, Yang…[et al.]. Preliminary Study of Quercetin Affecting the Hypothalamic-Pituitary-Gonadal Axis on Rat Endometriosis Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1019036
American Medical Association (AMA)
Cao, Yang& Zhuang, Meng-fei& Yang, Ying& Xie, Shu-wu& Cui, Jin-gang& Cao, Lin…[et al.]. Preliminary Study of Quercetin Affecting the Hypothalamic-Pituitary-Gonadal Axis on Rat Endometriosis Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1019036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1019036