White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats
Joint Authors
Liang, Yong-Zhuo
Chen, Hai-Ming
Su, Zu-Qing
Hou, Shao-Zhen
Chen, Xiao-Ying
Zheng, Yi-Feng
Li, Yu-Cui
Lin, Ji
Zhan, Janis Ya-Xian
Su, Zi-Ren
Fu, Lu-Di
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats.
Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400 mg/kg) or intravenous injection (40 mg/kg) of puerarin, pretreated with or without white pepper and piperine given orally.
Compared to the control group given oral puerarin only, the combined use of piperine (10 or 20 mg/kg) increased the Cmax of puerarin by 1.30-fold or 1.64-fold and the AUC0–∞ by 133% or 157%, respectively.
In contrast, coadministration of white pepper (125 or 250 mg/kg) decreased oral absorption of puerarin to 83% or 74%, respectively.
On the other hand, pretreatment with piperine orally did not alter the intravenous pharmacokinetics of puerarin, while the AUC of puerarin after intravenous administration was increased by pretreatment with white pepper.
The results indicate that pretreatment with piperine or pepper exerts different effects on pharmacokinetics of puerarin administrated via intragastric and intravenous routes.
Therefore, it is suggested that the combined application of piperine or white pepper with puerarin should be carefully monitored for potential diet-drug interactions.
American Psychological Association (APA)
Liang, Yong-Zhuo& Chen, Hai-Ming& Su, Zu-Qing& Hou, Shao-Zhen& Chen, Xiao-Ying& Zheng, Yi-Feng…[et al.]. 2014. White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1020277
Modern Language Association (MLA)
Liang, Yong-Zhuo…[et al.]. White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1020277
American Medical Association (AMA)
Liang, Yong-Zhuo& Chen, Hai-Ming& Su, Zu-Qing& Hou, Shao-Zhen& Chen, Xiao-Ying& Zheng, Yi-Feng…[et al.]. White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1020277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1020277