Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model
Joint Authors
Cao, Peng-Chong
Xiao, Wen-Xing
Yan, Ya-Bo
Zhao, Xiong
Liu, Shuai
Feng, Jing
Zhang, Wei
Wang, Jun
Feng, Ya-Fei
Lei, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The purpose of this study was to investigate the therapeutic effects of crocin on ovariectomy-induced osteoporosis in rats.
Female Sprague-Dawley rats were randomly assigned to a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), OVX with 17β-estradiol (E 2, 25 μg/kg/day), and OVX with graded crocin doses (5, 10, or 20 mg/kg/day).
Daily oral administration of E 2 or crocin started 4 weeks after OVX and lasted for 16 weeks.
Our results showed that crocin dose-dependently inhibited the BMD reduction of L4 vertebrae and femurs caused by OVX and prevented the deterioration of trabecular microarchitecture, which were accompanied by a significant decrease in skeletal remodeling as evidenced by the lower levels of bone turnover markers.
Furthermore, crocin reversed the oxidative stress status in both serum and bone tissue.
The present study indicates that the administration of crocin at higher doses over a 16-week period can prevent OVX-induced osteoporosis in rats without hyperplastic effects on the uterus, which may, at least partially, be attributed to crocin’s antioxidative property.
In brief, crocin is a natural alternative for postmenopausal osteoporosis treatment in elderly women.
American Psychological Association (APA)
Cao, Peng-Chong& Xiao, Wen-Xing& Yan, Ya-Bo& Zhao, Xiong& Liu, Shuai& Feng, Jing…[et al.]. 2014. Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1020294
Modern Language Association (MLA)
Cao, Peng-Chong…[et al.]. Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1020294
American Medical Association (AMA)
Cao, Peng-Chong& Xiao, Wen-Xing& Yan, Ya-Bo& Zhao, Xiong& Liu, Shuai& Feng, Jing…[et al.]. Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1020294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1020294