Effects and Mechanisms of Transcutaneous Electroacupuncture on Chemotherapy-Induced Nausea and Vomiting
Joint Authors
Chen, Jiande DZ
Zhang, Xing
Jin, Hai-feng
Fan, Yi-hong
LU, Bin
Meng, Li-na
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Nausea and vomiting are one of the major complications of chemotherapy for cancers.
The aim of this study is to investigate the emetic effects and mechanisms involving serotonin and dopamine of needleless transcutaneous electroacupuncture (TEA) at Neiguan (PC6) and Jianshi (PC5) on chemotherapy-induced nausea and vomiting in patients with cancers.
Seventy-two patients with chemotherapy were randomly divided into sham-TEA group (sham-TEA, n = 34 ) and TEA group ( n = 38 ) .
TEA was performed at PC 6 and PC 5 (1 h, bid) in combination with granisetron.
Sham-TEA was delivered at nonacupoints using the same parameters.
We found the following.
(1) In the acute phase, the conventional antiemetic therapy using Ondansetron effectively reduced nausea and vomiting; the addition of TEA did not show any additive effects.
In the delayed phase, however, TEA significantly increased the rate of complete control ( P < 0.01 ) and reduced the nausea score ( P < 0.05 ) , compared with sham-TEA.
(2) TEA significantly reduced serum levels of 5-HT and dopamine in comparison with sham-TEA.
Those results demonstrate that needleless transcutaneous electroacupuncture at PC6 using a watch-size digital stimulator improves emesis and reduces nausea in the delayed phase of chemotherapy in patients with cancers.
This antiemetic effect is possibly mediated via mechanisms involving serotonin and dopamine.
American Psychological Association (APA)
Zhang, Xing& Jin, Hai-feng& Fan, Yi-hong& LU, Bin& Meng, Li-na& Chen, Jiande DZ. 2014. Effects and Mechanisms of Transcutaneous Electroacupuncture on Chemotherapy-Induced Nausea and Vomiting. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1020351
Modern Language Association (MLA)
Zhang, Xing…[et al.]. Effects and Mechanisms of Transcutaneous Electroacupuncture on Chemotherapy-Induced Nausea and Vomiting. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1020351
American Medical Association (AMA)
Zhang, Xing& Jin, Hai-feng& Fan, Yi-hong& LU, Bin& Meng, Li-na& Chen, Jiande DZ. Effects and Mechanisms of Transcutaneous Electroacupuncture on Chemotherapy-Induced Nausea and Vomiting. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1020351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1020351