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Ginsenosides Rb1 and Rg1 Stimulate Melanogenesis in Human Epidermal Melanocytes via PKACREBMITF Signaling
Joint Authors
Lin, Mao
Zhang, Bao-Xiang
Zhang, Ci
Shen, Nan
Zhang, Yun-Ying
Wang, Ao-Xue
Tu, Cai-Xia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Reduced or defective melanin skin pigmentation may cause many hypopigmentation disorders and increase the risk of damage to the skin triggered by UV irradiation.
Ginsenosides Rb1 and Rg1 have many molecular targets including the cAMP-response element-binding protein (CREB), which is involved in melanogenesis.
This study aimed to investigate the effects of ginsenosides Rb1 and Rg1 on melanogenesis in human melanocytes and their related mechanisms.
The effects of Rb1 and Rg1 on cell viability, tyrosinase activity, cellular melanin content and protein levels of tyrosinase, microphthalmia-associated transcription factor (MITF), and activation of CREB in melanocytes were assessed.
Results showed that Rb1 or Rg1 significantly increased cellular melanin content and tyrosinase activity in a dose-dependent manner.
By contrast, the cell viability of melanocytes remained unchanged.
After exposure to Rb1 or Rg1, the protein levels of tyrosinase, MITF, and phosphorylated CREB were significantly increased.
Furthermore, pretreatment with the selective PKA inhibitor H-89 significantly blocked the Rb1- or Rg1-induced increase of melanin content.
These findings indicated that Rb1 and Rg1 increased melanogenesis and tyrosinase activity in human melanocytes, which was associated with activation of PKA/CREB/MITF signaling.
The effects and mechanisms of Rb1 or Rg1 on skin pigmentation deserve further study.
American Psychological Association (APA)
Lin, Mao& Zhang, Bao-Xiang& Zhang, Ci& Shen, Nan& Zhang, Yun-Ying& Wang, Ao-Xue…[et al.]. 2014. Ginsenosides Rb1 and Rg1 Stimulate Melanogenesis in Human Epidermal Melanocytes via PKACREBMITF Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1020375
Modern Language Association (MLA)
Lin, Mao…[et al.]. Ginsenosides Rb1 and Rg1 Stimulate Melanogenesis in Human Epidermal Melanocytes via PKACREBMITF Signaling. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1020375
American Medical Association (AMA)
Lin, Mao& Zhang, Bao-Xiang& Zhang, Ci& Shen, Nan& Zhang, Yun-Ying& Wang, Ao-Xue…[et al.]. Ginsenosides Rb1 and Rg1 Stimulate Melanogenesis in Human Epidermal Melanocytes via PKACREBMITF Signaling. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1020375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1020375