Anticancer effects of tow traditional drinks hibiscus (Hibiscus sabdariffa linn)‎ and liquorice (Glycyrrhiza glabra)‎

Abstract EN

Breast cancer (MCF-7), as well as liver cancer (HepG2), were the leader among newcancer cases.

The objective of this study is to assess the viability percentage of tow traditional drinks(hibiscus and liquorice extracts) toward human breast and liver cancer cell lines at differentconcentrates from 250 to 5000 μg/ml in hibiscus extract and from 50 to 3000 μg/ml in liquoriceextract.

The viability percentage of hibiscus on breast and liver cancer cell lines were 86.9% and84.7% at 5000 μg/ml, respectively.

The IC50 of the hibiscus extract were 18478.6 μg/ml and 16159μg/ml breast and liver cancer.

In addition, the viability percentage of liquorice extract on breast andliver cancer cell lines were determined.

Results revealed that liquorice extract has possessed high anticarcinogenicproperties it was zero (% ) at 3000 μg/ml for breast cancer and 5% for liver cancer atsame concentration, the IC50 was 491.7 μg/ml in breast cancer and was 125 μg/ml in liver cancer cellline.

DNA damage was determined to detect oxidative DNA damage in HepG2 cell line.

This enhances therole of these traditional drinks especially liquorice as anti-cancer agents.