Studies on theileriosis in crossbred calves before and after treatment by buparva-quone under the effect of local conditions in upper Egypt

Abstract EN

This study aimed to estimate the drastic effects of Theiler a annulated infection on the general health condition and some hematological and biochemical parameters and to evaluate the efficacy of Buparvaquone in treatment of crossbred calves.

Bup-arvaquone was injected at a dose rate of 2.5 mg/kg BW as a single dose (group A) or double doses with 48 h intervals (group B).The rate of Parasitaemia in the infected calves reached 12-28 %.Pyre-xia reached 40.5-41.3°C.

Anemia was a hall-mark of the disease accompanied by reduction of the mean values of blood serum total protein, albumin, globulin, glucose, cholesterol, calcium, and phosphorous while non-significant changes in the concentrations of blood serum triglycerides and magnesium were recorded if compared to the non-infected control calves (group C).

Animals in group A showed elevated rectal temperature (40-40.6°C) for 5-8 days and the rate of parasitaemia declined slowly till it reached its minimal level (4.5 %) 20 days post treatment (PT).

Also, 2 calves were died at the day 7 and 8 PT with high rate of parasitaemia (33-41 %) and pyrexia (41.6°C).

In group B, the temperature subsided 1-2 days after the 2nd dose and the rate of parasitaemia reached to less than 1% at the day 12.Haematological parameters remained reduced PT in group A, while they restored their normal values except total leucocyte count in group B.

Biochemical parameters were restored except serum globulin concentration in group B, which remained in group A.

From these investigations we can concluded that buparvaquone at a dose rate 2.5 mg / kg BW in double dose with 48 h intervals is more efficient than a single dose under the local environment of Upper Egypt.