Individually Tailored Screening of Susceptibility to Sarcopenia Using p53 Codon 72 Polymorphism, Phenotypes, and Conventional Risk Factors

Abstract EN

Background and Aim.

p53 activity plays a role in muscle homeostasis and skeletal muscle differentiation; all pathways that lead to sarcopenia are related to p53 activities.

We investigate the allelic frequency of the TP53 codon 72 in exon 4 polymorphism in the Italian female population and the association with appendicular skeletal muscle mass index in normal weight (NW), normal weight obese (NWO), and preobese-obese (Preob-Ob) subjects.

Methods.

We evaluated anthropometry, body composition, and p53 polymorphism in 140 women distinguished in NW, NWO, and Preob-Ob.

Results.

Arg * / Arg * genotype increases sarcopenia risk up to 20% ( Arg * / Arg * genotype OR = 1.

20; 95% CI = 0.

48– 2.

9; proallele * carriers OR = 0.

83; 95% CI = 0.

83– 2.

06).

The risk of being sarcopenic for Arg * / Arg * genotype in NWO and Preob-Ob is 31% higher than NW carriers of proallele * (RR = 0, 31, 95% CI = 0, 15– 0, 66, P = 0, 0079).

We developed a model able to predict sarcopenia risk based on age, body fat, and p53 polymorphism.

Conclusion.

Our study evidences that genotyping TP53 polymorphism could be a useful new genetic approach, in association with body composition evaluations, to assess sarcopenia risk.