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AGEs and Glucose Levels Modulate Type I and III Procollagen mRNA Synthesis in Dermal Fibroblasts Cells Culture
Joint Authors
Anca, Dinischiotu
Marieta, Costache
Andreea, Serban Iren
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In the dermis, fibroblasts play an important role in the turnover of the dermal extracellular matrix.
Collagen I and III, the most important dermal proteins of the extracellular matrix, are progressively altered during ageing and diabetes.
For mimicking diabetic conditions, the cultured human dermal fibroblasts were incubated with increasing amounts of AGE-modified BSA and D-glucose for 24 hours.
The expression of procollagen α2(I) and procollagen α1(III) mRNA was analyzed by quantitative real-time PCR.
Our data revealed that the treatment of fibroblasts with AGE-modified BSA upregulated the expression of procollagen α2(I) and procollagen α1(III) mRNA in a dose-dependent manner.
High glucose levels mildly induced a profibrogenic pattern, increasing the procollagen α2(I) mRNA expression whereas there was a downregulation tendency of procollagen α1(III) mRNA.
American Psychological Association (APA)
Andreea, Serban Iren& Marieta, Costache& Anca, Dinischiotu. 2008. AGEs and Glucose Levels Modulate Type I and III Procollagen mRNA Synthesis in Dermal Fibroblasts Cells Culture. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-1027050
Modern Language Association (MLA)
Andreea, Serban Iren…[et al.]. AGEs and Glucose Levels Modulate Type I and III Procollagen mRNA Synthesis in Dermal Fibroblasts Cells Culture. Journal of Diabetes Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-1027050
American Medical Association (AMA)
Andreea, Serban Iren& Marieta, Costache& Anca, Dinischiotu. AGEs and Glucose Levels Modulate Type I and III Procollagen mRNA Synthesis in Dermal Fibroblasts Cells Culture. Journal of Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-1027050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027050