Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris
Joint Authors
Narbutt, Joanna
Sysa-Jedrzejowska, Anna
Lesiak, Aleksandra
Torzecka, Jolanta Dorota
Bogaczewicz, Jarosław
Lukamowicz, Jolanta
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
As most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-α, IL-1, and IL-6 in PV patients in clinical remission.
The study group consisted of sera from 19 PV patients in active stage and from 24 patients in clinical remission.
19 sera taken from healthy subjects served as the controls.
Serum IL-6 concentrations in PV active and PV remission group were significantly higher when compared to the controls (P<.05).
In patients in active stage of PV, a significant correlation between serum IL-1 and IL-6 concentrations was found (rP=0.46;P<.05).
We also found a negative correlation between TNF-α level and pemphigus antibodies titer in the patients from the remission group (rS=−0.47303;P<.02).
Our data suggest that IL-6 and TNF-α may be involved in maintaining immunological disturbances in remission stage of PV.
American Psychological Association (APA)
Narbutt, Joanna& Lukamowicz, Jolanta& Bogaczewicz, Jarosław& Sysa-Jedrzejowska, Anna& Torzecka, Jolanta Dorota& Lesiak, Aleksandra. 2008. Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-1027059
Modern Language Association (MLA)
Narbutt, Joanna…[et al.]. Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris. Mediators of Inflammation No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-1027059
American Medical Association (AMA)
Narbutt, Joanna& Lukamowicz, Jolanta& Bogaczewicz, Jarosław& Sysa-Jedrzejowska, Anna& Torzecka, Jolanta Dorota& Lesiak, Aleksandra. Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-1027059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027059