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Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies
Joint Authors
Phipps, Richard P.
Lehmann, Geniece M.
Sime, Patricia J.
Bernstein, Steven H.
Garcia-Bates, Tatiana M.
Simpson-Haidaris, P. J.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-23
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor gamma (PPARγ) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis.
PPARγ is expressed in a variety of immune cells as well as in numerous leukemias and lymphomas.
Here, we review recent studies that provide new insights into the mechanisms by which PPARγ ligands influence hematological malignant cell growth, differentiation, and survival.
Understanding the diverse properties of PPARγ ligands is crucial for the development of new therapeutic approaches for hematological malignancies.
American Psychological Association (APA)
Garcia-Bates, Tatiana M.& Lehmann, Geniece M.& Simpson-Haidaris, P. J.& Bernstein, Steven H.& Sime, Patricia J.& Phipps, Richard P.. 2008. Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies. PPAR Research،Vol. 2008, no. 2008, pp.1-18.
https://search.emarefa.net/detail/BIM-1027065
Modern Language Association (MLA)
Garcia-Bates, Tatiana M.…[et al.]. Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies. PPAR Research No. 2008 (2008), pp.1-18.
https://search.emarefa.net/detail/BIM-1027065
American Medical Association (AMA)
Garcia-Bates, Tatiana M.& Lehmann, Geniece M.& Simpson-Haidaris, P. J.& Bernstein, Steven H.& Sime, Patricia J.& Phipps, Richard P.. Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-18.
https://search.emarefa.net/detail/BIM-1027065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027065