Regulation of Lymphocyte Function by PPARγ: Relevance to Thyroid Eye Disease-Related Inflammation
Joint Authors
Phipps, Richard P.
Feldon, S. E.
Lehmann, Geniece M.
Smith, T. J.
Garcia-Bates, Tatiana M.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-12-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Thyroid eye disease (TED) is an autoimmune condition in which intense inflammation leads to orbital tissue remodeling, including the accumulation of extracellular macromolecules and fat.
Disease progression depends upon interactions between lymphocytes and orbital fibroblasts.
These cells engage in a cycle of reciprocal activation which produces the tissue characteristics of TED.
Peroxisome proliferator-activated receptor-γ (PPARγ) may play divergent roles in this process, both attenuating and promoting disease progression.
PPARγ has anti-inflammatory activity, suggesting that it could interrupt intercellular communication.
However, PPARγ activation is also critical to adipogenesis, making it a potential culprit in the pathological fat accumulation associated with TED.
This review explores the role of PPARγ in TED, as it pertains to crosstalk between lymphocytes and fibroblasts and the development of therapeutics targeting cell-cell interactions mediated through this signaling pathway.
American Psychological Association (APA)
Lehmann, Geniece M.& Garcia-Bates, Tatiana M.& Smith, T. J.& Feldon, S. E.& Phipps, Richard P.. 2007. Regulation of Lymphocyte Function by PPARγ: Relevance to Thyroid Eye Disease-Related Inflammation. PPAR Research،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-1027066
Modern Language Association (MLA)
Lehmann, Geniece M.…[et al.]. Regulation of Lymphocyte Function by PPARγ: Relevance to Thyroid Eye Disease-Related Inflammation. PPAR Research No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-1027066
American Medical Association (AMA)
Lehmann, Geniece M.& Garcia-Bates, Tatiana M.& Smith, T. J.& Feldon, S. E.& Phipps, Richard P.. Regulation of Lymphocyte Function by PPARγ: Relevance to Thyroid Eye Disease-Related Inflammation. PPAR Research. 2007. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-1027066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027066