Purple Sweet Potato Color Ameliorates Cognition Deficits and Attenuates Oxidative Damage and Inflammation in Aging Mouse Brain Induced by D-Galactose
Joint Authors
Mao, Zhen
Ma, Daifu
Zhou, Zhong
Hu, Bin
Shan, Qun
Lu, Jun
Zheng, Yuanlin
Fan, Shaohua
Li, Jing
Zhang, Zifeng
Wang, Yong-jian
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purple sweet potato color (PSPC), a naturally occurring anthocyanin, has a powerful antioxidant activity in vitro and in vivo.
This study explores whether PSPC has the neuroprotective effect on the aging mouse brain induced by D-galactose (D-gal).
The mice administrated with PSPC (100 mg/kg.day, 4 weeks, from 9th week) via oral gavage showed significantly improved behavior performance in the open field and passive avoidance test compared with D-gal-treated mice (500 mg/kg.day, 8 weeks).
We further investigate the mechanism involved in neuroprotective effects of PSPC on mouse brain.
Interestingly, we found, PSPC decreased the expression level of glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), inhibited nuclear translocation of nuclear factor-kappaB (NF-κB), increased the activity of copper/zinc superoxide dismutase (Cu/Zn-SOD) and catalase (CAT), and reduced the content of malondialdehyde (MDA), respectively.
Our data suggested that PSPC attenuated D-gal-induced cognitive impairment partly via enhancing the antioxidant and anti-inflammatory capacity.
American Psychological Association (APA)
Shan, Qun& Lu, Jun& Zheng, Yuanlin& Li, Jing& Zhou, Zhong& Hu, Bin…[et al.]. 2009. Purple Sweet Potato Color Ameliorates Cognition Deficits and Attenuates Oxidative Damage and Inflammation in Aging Mouse Brain Induced by D-Galactose. BioMed Research International،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-1027096
Modern Language Association (MLA)
Shan, Qun…[et al.]. Purple Sweet Potato Color Ameliorates Cognition Deficits and Attenuates Oxidative Damage and Inflammation in Aging Mouse Brain Induced by D-Galactose. BioMed Research International No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-1027096
American Medical Association (AMA)
Shan, Qun& Lu, Jun& Zheng, Yuanlin& Li, Jing& Zhou, Zhong& Hu, Bin…[et al.]. Purple Sweet Potato Color Ameliorates Cognition Deficits and Attenuates Oxidative Damage and Inflammation in Aging Mouse Brain Induced by D-Galactose. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-1027096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027096