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Pre-mRNA Processing Is Partially Impaired in Satellite Cell Nuclei from Aged Muscles
Joint Authors
Malatesta, Manuela
Perdoni, Federica
Pellicciari, Carlo
Zancanaro, Carlo
Muller, Sylviane
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Satellite cells are responsible for the capacity of mature mammalian skeletal muscles to repair and maintain mass.
During aging, skeletal muscle mass as well as the muscle strength and endurance progressively decrease, leading to a condition termed sarcopenia.
The causes of sarcopenia are manifold and remain to be completely elucidated.
One of them could be the remarkable decline in the efficiency of muscle regeneration; this has been associated with decreasing amounts of satellite cells, but also to alterations in their activation, proliferation, and/or differentiation.
In this study, we investigated the satellite cell nuclei of biceps and quadriceps muscles from adult and old rats; morphometry and immunocytochemistry at light and electron microscopy have been combined to assess the organization of the nuclear RNP structural constituents involved in different steps of mRNA formation.
We demonstrated that in satellite cells the RNA pathways undergo alterations during aging, possibly hampering their responsiveness to muscle damage.
American Psychological Association (APA)
Malatesta, Manuela& Perdoni, Federica& Muller, Sylviane& Pellicciari, Carlo& Zancanaro, Carlo. 2010. Pre-mRNA Processing Is Partially Impaired in Satellite Cell Nuclei from Aged Muscles. BioMed Research International،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-1027142
Modern Language Association (MLA)
Malatesta, Manuela…[et al.]. Pre-mRNA Processing Is Partially Impaired in Satellite Cell Nuclei from Aged Muscles. BioMed Research International No. 2010 (Dec. 2010), pp.1-9.
https://search.emarefa.net/detail/BIM-1027142
American Medical Association (AMA)
Malatesta, Manuela& Perdoni, Federica& Muller, Sylviane& Pellicciari, Carlo& Zancanaro, Carlo. Pre-mRNA Processing Is Partially Impaired in Satellite Cell Nuclei from Aged Muscles. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-1027142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027142