Identification of microRNAs Involved in the Host Response to Enterovirus 71 Infection by a Deep Sequencing Approach
Joint Authors
Guo, Xiling
Ge, Yiyue
Shan, Jun
Wang, Hua
Qi, Yuhua
Shan, Yunfeng
Cui, Lunbiao
Shi, Zhiyang
Zhu, Zheng
Wu, Tao
Qi, Xian
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Role of microRNA (miRNA) has been highlighted in pathogen-host interactions recently.
To identify cellular miRNAs involved in the host response to enterovirus 71 (EV71) infection, we performed a comprehensive miRNA profiling in EV71-infected Hep2 cells through deep sequencing.
64 miRNAs were found whose expression levels changed for more than 2-fold in response to EV71 infection.
Gene ontology analysis revealed that many of these mRNAs play roles in neurological process, immune response, and cell death pathways, which are known to be associated with the extreme virulence of EV71.
To our knowledge, this is the first study on host miRNAs expression alteration response to EV71 infection.
Our findings supported the hypothesis that certain miRNAs might be essential in the host-pathogen interactions.
American Psychological Association (APA)
Cui, Lunbiao& Guo, Xiling& Qi, Yuhua& Qi, Xian& Ge, Yiyue& Shi, Zhiyang…[et al.]. 2010. Identification of microRNAs Involved in the Host Response to Enterovirus 71 Infection by a Deep Sequencing Approach. BioMed Research International،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-1027143
Modern Language Association (MLA)
Cui, Lunbiao…[et al.]. Identification of microRNAs Involved in the Host Response to Enterovirus 71 Infection by a Deep Sequencing Approach. BioMed Research International No. 2010 (Dec. 2010), pp.1-8.
https://search.emarefa.net/detail/BIM-1027143
American Medical Association (AMA)
Cui, Lunbiao& Guo, Xiling& Qi, Yuhua& Qi, Xian& Ge, Yiyue& Shi, Zhiyang…[et al.]. Identification of microRNAs Involved in the Host Response to Enterovirus 71 Infection by a Deep Sequencing Approach. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-1027143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027143
