The Role of the Lactadherin in Promoting Intestinal DCs Development In Vivo and Vitro
Joint Authors
Yuan, Xiang-Liang
Zhou, Yi-Jun
Yang, Hua-Mei
Gao, Juan
Chen, Tong-Xin
He, Zhen-Juan
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lactadherin, as one of the immune components in the breast milk, might play a role in the intestinal immune system of newborn.
Therefore, we investigated the effect of lactadherin-feeding in early time on the development of intestinal immune system compared with naturally rearing and artificially rearing (non-lactadherin).
In the present study, we observed that the Peyer's Patches (PP) from the pups of artificially reared group with lactadherin added were characterized by an excess of OX62+CD4+SIRP+ DC cells and a higher expression of CD3+CD4+CD25+T cells.
Additionally, this study also demonstrated that IL-10 production was dramatically increased when lactadherin was present in culture medium compared with lactadherin-absent culture.
These results suggested that lactadherin could adjust intestinal DCs activity, induce CD3+CD4+CD25+T cell differentiation, and enhance IL-10 production.
American Psychological Association (APA)
Zhou, Yi-Jun& Gao, Juan& Yang, Hua-Mei& Yuan, Xiang-Liang& Chen, Tong-Xin& He, Zhen-Juan. 2010. The Role of the Lactadherin in Promoting Intestinal DCs Development In Vivo and Vitro. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-1027165
Modern Language Association (MLA)
Zhou, Yi-Jun…[et al.]. The Role of the Lactadherin in Promoting Intestinal DCs Development In Vivo and Vitro. Journal of Immunology Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-1027165
American Medical Association (AMA)
Zhou, Yi-Jun& Gao, Juan& Yang, Hua-Mei& Yuan, Xiang-Liang& Chen, Tong-Xin& He, Zhen-Juan. The Role of the Lactadherin in Promoting Intestinal DCs Development In Vivo and Vitro. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-1027165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027165