Prognostic and Diagnostic Value of Spontaneous Tumor-Related Antibodies

Joint Authors

Luetkens, Tim
Cao, Yanran
Bokemeyer, Carsten
Kobold, Sebastian
Atanackovic, Djordje

Source

Journal of Immunology Research

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-12-08

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Biology

Abstract EN

There is an urgent need for earlier diagnosis of malignancies and more stringent monitoring of relapses after antitumor therapy.

In addition, new prognostic markers are needed for risk stratification and design of individualized cancer therapies.

New diagnostic and prognostic parameters should overcome the impairments of current standards in a cost-effective manner.

Serological approaches measuring spontaneous antibody responses against tumor-associated antigens could be of use as diagnostic and prognostic markers and could also be employed to evaluate response to therapy in cancer patients.

Autoantibodies have been suggested to be of frequent and specific occurrence in patients with malignancies and to correlate with clinical parameters.

Screening the relevant literature on this topic, we suggest that the analysis of single antibody specificities is unlikely to provide sufficient diagnostic and prognostic accuracy.

The combined analysis of autoantibodies targeting different antigens, however, may reach high sensitivity and specificity.

In addition, screening cancer patients for autoantibodies might identify subgroups with high relapse risk and a worse prognosis.

Larger prospective trials should be initiated to identify sets of tumor-associated autoantibodies suited for the use in diagnostic algorithms for cancer detection and followup.

American Psychological Association (APA)

Kobold, Sebastian& Luetkens, Tim& Cao, Yanran& Bokemeyer, Carsten& Atanackovic, Djordje. 2010. Prognostic and Diagnostic Value of Spontaneous Tumor-Related Antibodies. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-1027167

Modern Language Association (MLA)

Kobold, Sebastian…[et al.]. Prognostic and Diagnostic Value of Spontaneous Tumor-Related Antibodies. Journal of Immunology Research No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-1027167

American Medical Association (AMA)

Kobold, Sebastian& Luetkens, Tim& Cao, Yanran& Bokemeyer, Carsten& Atanackovic, Djordje. Prognostic and Diagnostic Value of Spontaneous Tumor-Related Antibodies. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-1027167

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1027167