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Investigation of Hepatoprotective Activity of Induced Pluripotent Stem Cells in the Mouse Model of Liver Injury
Joint Authors
Huang, Hsu-Shan
Huang, Hui-Chun
Hsieh, Jung-Hung
Lee, Shou-Dong
Chang, Ching-Chih
Chen, Yi-Jen
Hung, Shuen-Iu
Jeng, Shaw-Yeu
Chiou, Shih Hwa
Tsai, Ping-Hsing
Chiang, Chih-Hung
Lee, Fa-Yauh
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
To date liver transplantation is the only effective treatment for end-stage liver diseases.
Considering the potential of pluripotency and differentiation into tridermal lineages, induced pluripotent stem cells (iPSCs) may serve as an alternative of cell-based therapy.
Herein, we investigated the effect of iPSC transplantation on thioacetamide- (TAA-) induced acute/fulminant hepatic failure (AHF) in mice.
Firstly, we demonstrated that iPSCs had the capacity to differentiate into hepatocyte-like cells (iPSC-Heps) that expressed various hepatic markers, including albumin, α-fetoprotein, and hepatocyte nuclear factor-3β, and exhibited biological functions.
Intravenous transplantation of iPSCs effectively reduced the hepatic necrotic area, improved liver functions and motor activity, and rescued TAA-treated mice from lethal AHF.
1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate cell labeling revealed that iPSCs potentially mobilized to the damaged liver area.
Taken together, iPSCs can effectively rescue experimental AHF and represent a potentially favorable cell source of cell-based therapy.
American Psychological Association (APA)
Chiang, Chih-Hung& Chang, Ching-Chih& Huang, Hui-Chun& Chen, Yi-Jen& Tsai, Ping-Hsing& Jeng, Shaw-Yeu…[et al.]. 2011. Investigation of Hepatoprotective Activity of Induced Pluripotent Stem Cells in the Mouse Model of Liver Injury. BioMed Research International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-1027604
Modern Language Association (MLA)
Chiang, Chih-Hung…[et al.]. Investigation of Hepatoprotective Activity of Induced Pluripotent Stem Cells in the Mouse Model of Liver Injury. BioMed Research International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-1027604
American Medical Association (AMA)
Chiang, Chih-Hung& Chang, Ching-Chih& Huang, Hui-Chun& Chen, Yi-Jen& Tsai, Ping-Hsing& Jeng, Shaw-Yeu…[et al.]. Investigation of Hepatoprotective Activity of Induced Pluripotent Stem Cells in the Mouse Model of Liver Injury. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-1027604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027604