Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection
Joint Authors
Chiu, Yung-Tsung
Lin, Nai-Nu
Lee, Yen-Feng
Cheng, Ching-Chang
Wu, Chieh-Liang
Tung, Kwong-Chung
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bronchiolitis obliterans organizing pneumonia (BOOP) is a chronic respiratory disease.
Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis.
In our five pigs with chronic postweaning multisystemic wasting syndrome (PMWS), typical BOOP lesions were revealed.
All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2) was identified.
They also exhibited similar pathologic findings such as proliferation of type II pneumocytes and myofibroblasts (MFBs), extracellular collagen matrix (ECM) deposition, and fragmentation of elastic fibers.
MFBs migration correlative molecules, for instance, gelatinase A, B and osteopontin, appeared strongly in the progressing marginal area of polypoid intraluminal plugs of fibrotic lesion.
These molecules colocalized with the active MFBs.
Both gelatinase activity and intercellular level of active MFBs were significantly increased (P<.05).
Porcine chronic bronchopneumonia leads to BOOP and it is associated with PCV2 persistent infection.
Swine BOOP demonstrates similar cellular constituents with human BOOP.
Perhaps their molecular mechanisms of pathogenesis operate in a similar way.
Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection.
Moreover, it is more convenient to obtain samples.
American Psychological Association (APA)
Cheng, Ching-Chang& Lee, Yen-Feng& Lin, Nai-Nu& Wu, Chieh-Liang& Tung, Kwong-Chung& Chiu, Yung-Tsung. 2010. Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027606
Modern Language Association (MLA)
Cheng, Ching-Chang…[et al.]. Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-1027606
American Medical Association (AMA)
Cheng, Ching-Chang& Lee, Yen-Feng& Lin, Nai-Nu& Wu, Chieh-Liang& Tung, Kwong-Chung& Chiu, Yung-Tsung. Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027606