![](/images/graphics-bg.png)
Long-Term Type 1 Diabetes Enhances In-Stent Restenosis after Aortic Stenting in Diabetes-Prone BB Rats
Joint Authors
Groenewegen, Hendrik C.
Klatter, Flip A.
de Smet, Bart J. G. L.
Goris, Maaike
van Goor, Harry
Rozing, Jan
Hillebrands, Jan-Luuk
Onuta, Geanina
Roks, Anton J. M.
Walther Boer, Mark
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Type 1 diabetic patients have increased risk of developing in-stent restenosis following endovascular stenting.
Underlying pathogenetic mechanisms are not fully understood partly due to the lack of a relevant animal model to study the effect(s) of long-term autoimmune diabetes on development of in-stent restenosis.
We here describe the development of in-stent restenosis in long-term (~7 months) spontaneously diabetic and age-matched, thymectomized, nondiabetic Diabetes Prone BioBreeding (BBDP) rats (n=6-7 in each group).
Diabetes was suboptimally treated with insulin and was characterized by significant hyperglycaemia, polyuria, proteinuria, and increased HbA1c levels.
Stented abdominal aortas were harvested 28 days after stenting.
Computerized morphometric analysis revealed significantly increased neointima formation in long-term diabetic rats compared with nondiabetic controls.
In conclusion, long-term autoimmune diabetes in BBDP rats enhances in-stent restenosis.
This model can be used to study the underlying pathogenetic mechanisms of diabetes-enhanced in-stent restenosis as well as to test new therapeutic modalities.
American Psychological Association (APA)
Onuta, Geanina& Groenewegen, Hendrik C.& Klatter, Flip A.& Walther Boer, Mark& Goris, Maaike& van Goor, Harry…[et al.]. 2011. Long-Term Type 1 Diabetes Enhances In-Stent Restenosis after Aortic Stenting in Diabetes-Prone BB Rats. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-1027610
Modern Language Association (MLA)
Onuta, Geanina…[et al.]. Long-Term Type 1 Diabetes Enhances In-Stent Restenosis after Aortic Stenting in Diabetes-Prone BB Rats. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-1027610
American Medical Association (AMA)
Onuta, Geanina& Groenewegen, Hendrik C.& Klatter, Flip A.& Walther Boer, Mark& Goris, Maaike& van Goor, Harry…[et al.]. Long-Term Type 1 Diabetes Enhances In-Stent Restenosis after Aortic Stenting in Diabetes-Prone BB Rats. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-1027610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027610