Neurotrophic Features of Human Adipose Tissue-Derived Stromal Cells: In Vitro and In Vivo Studies
Joint Authors
Corvino, Valentina
Geloso, Maria Concetta
Saulnier, Nathalie
Giannetti, Stefano
Gasbarrini, Antonio
Lattanzi, Wanda
Michetti, Fabrizio
Puglisi, Maria Ausiliatrice
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Due to its abundance, easy retrieval, and plasticity characteristics, adipose-tissue-derived stromal cells (ATSCs) present unquestionable advantages over other adult-tissue-derived stem cells.
Based on the in silico analysis of our previous data reporting the ATSC-specific expression profiles, the present study attempted to clarify and validate at the functional level the expression of the neurospecific genes expressed by ATSC both in vitro and in vivo.
This allowed evidencing that ATSCs express neuro-specific trophins, metabolic genes, and neuroprotective molecules.
They were in fact able to induce neurite outgrowth in vitro, along with tissue-specific commitment along the neural lineage and the expression of the TRKA neurotrophin receptor in vivo.
Our observation adds useful information to recent evidence proposing these cells as a suitable tool for cell-based applications in neuroregenerative medicine.
American Psychological Association (APA)
Lattanzi, Wanda& Geloso, Maria Concetta& Saulnier, Nathalie& Giannetti, Stefano& Puglisi, Maria Ausiliatrice& Corvino, Valentina…[et al.]. 2011. Neurotrophic Features of Human Adipose Tissue-Derived Stromal Cells: In Vitro and In Vivo Studies. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027613
Modern Language Association (MLA)
Lattanzi, Wanda…[et al.]. Neurotrophic Features of Human Adipose Tissue-Derived Stromal Cells: In Vitro and In Vivo Studies. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-1027613
American Medical Association (AMA)
Lattanzi, Wanda& Geloso, Maria Concetta& Saulnier, Nathalie& Giannetti, Stefano& Puglisi, Maria Ausiliatrice& Corvino, Valentina…[et al.]. Neurotrophic Features of Human Adipose Tissue-Derived Stromal Cells: In Vitro and In Vivo Studies. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027613