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Variability in Estrogen-Metabolizing Genes and Their Associationwith Genomic Instability in Untreated Breast Cancer Patients and Healthy Women
Joint Authors
Mayorano, Mônica Beatriz
Takahashi, Catarina Satie
Moreira de Andrade, Jurandyr
Alves dos Santos, Raquel
Carrara, Hélio Humberto Angotti
Teixeira, Ana Cláudia
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In the present study, we investigated the relationship between polymorphisms in the estrogen-metabolizing genes CYP17, CYP1B1, CYP1A1, and COMT and genomic instability in the peripheral blood lymphocytes of 62 BC patients and 62 controls considering that increased or prolonged exposure to estrogen can damage the DNA molecule and increase the genomic instability process in breast tissue.
Our data demonstrated increased genomic instability in BC patients and that individuals with higher frequencies of MN exhibited higher risk to BC when belonging Val/Met genotype of the COMT gene.
We also observed that CYP17 and CYP1A1 polymorphisms can modify the risk to BC depending on the menopause status.
We can conclude that the genetic background in estrogen metabolism pathway can modulate chromosome damage in healthy controls and patients and thereby influence the risk to BC.
These findings suggest the importance to ally biomarkers of susceptibility and effects to estimate risk groups.
American Psychological Association (APA)
Alves dos Santos, Raquel& Teixeira, Ana Cláudia& Mayorano, Mônica Beatriz& Carrara, Hélio Humberto Angotti& Moreira de Andrade, Jurandyr& Takahashi, Catarina Satie. 2011. Variability in Estrogen-Metabolizing Genes and Their Associationwith Genomic Instability in Untreated Breast Cancer Patients and Healthy Women. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027620
Modern Language Association (MLA)
Alves dos Santos, Raquel…[et al.]. Variability in Estrogen-Metabolizing Genes and Their Associationwith Genomic Instability in Untreated Breast Cancer Patients and Healthy Women. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-1027620
American Medical Association (AMA)
Alves dos Santos, Raquel& Teixeira, Ana Cláudia& Mayorano, Mônica Beatriz& Carrara, Hélio Humberto Angotti& Moreira de Andrade, Jurandyr& Takahashi, Catarina Satie. Variability in Estrogen-Metabolizing Genes and Their Associationwith Genomic Instability in Untreated Breast Cancer Patients and Healthy Women. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027620