Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers
Joint Authors
Reggiani, Carlo
D'Onofrio, Laura
Protasi, Feliciano
Quarta, Marco
Paolini, Cecilia
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We compared structure and function of EDL and Soleus muscles in adult (4–6 m) mice lacking both Calsequestrin (CASQ) isoforms, the main SR Ca2+-binding proteins.
Lack of CASQ induced ultrastructural alterations in ~30% of Soleus fibers, but not in EDL.
Twitch time parameters were prolonged in both muscles, although tension was not reduced.
However, when stimulated for 2 sec at 100 hz, Soleus was able to sustain contraction, while in EDL active tension declined by 70–80%.
The results presented in this paper unmask a differential effect of CASQ1&2 ablation in fast versus slow fibers.
CASQ is essential in EDL to provide large amount of Ca2+ released from the SR during tetanic stimulation.
In contrast, Soleus deals much better with lack of CASQ because slow fibers require lower Ca2+ amounts and slower cycling to function properly.
Nevertheless, Soleus suffers more severe structural damage, possibly because SR Ca2+ leak is more pronounced.
American Psychological Association (APA)
Paolini, Cecilia& Quarta, Marco& D'Onofrio, Laura& Reggiani, Carlo& Protasi, Feliciano. 2011. Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers. BioMed Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027623
Modern Language Association (MLA)
Paolini, Cecilia…[et al.]. Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers. BioMed Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-1027623
American Medical Association (AMA)
Paolini, Cecilia& Quarta, Marco& D'Onofrio, Laura& Reggiani, Carlo& Protasi, Feliciano. Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027623