Joint Inflammation and Early Degeneration Induced by High-Force Reaching Are Attenuated by Ibuprofen in an Animal Model of Work-Related Musculoskeletal Disorder
Joint Authors
Driban, Jeffrey B.
Barr, Ann E.
Barbe, Mary F.
Sitler, Michael R.
Amin, Mamta
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-20
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
We used our voluntary rat model of reaching and grasping to study the effect of performing a high-repetition and high-force (HRHF) task for 12 weeks on wrist joints.
We also studied the effectiveness of ibuprofen, administered in the last 8 weeks, in attenuating HRHF-induced changes in these joints.
With HRHF task performance, ED1+ and COX2+ cells were present in subchondral radius, carpal bones and synovium; IL-1alpha and TNF-alpha increased in distal radius/ulna/carpal bones; chondrocytes stained with Terminal deoxynucleotidyl Transferase- (TDT-) mediated dUTP-biotin nick end-labeling (TUNEL) increased in wrist articular cartilages; superficial structural changes (e.g., pannus) and reduced proteoglycan staining were observed in wrist articular cartilages.
These changes were not present in normal controls or ibuprofen treated rats, although IL-1alpha was increased in reach limbs of trained controls.
HRHF-induced increases in serum C1,2C (a biomarker of collagen I and II degradation), and the ratio of collagen degradation to synthesis (C1,2C/CPII; the latter a biomarker of collage type II synthesis) were also attenuated by ibuprofen.
Thus, ibuprofen treatment was effective in attenuating HRHF-induced inflammation and early articular cartilage degeneration.
American Psychological Association (APA)
Driban, Jeffrey B.& Barr, Ann E.& Amin, Mamta& Sitler, Michael R.& Barbe, Mary F.. 2010. Joint Inflammation and Early Degeneration Induced by High-Force Reaching Are Attenuated by Ibuprofen in an Animal Model of Work-Related Musculoskeletal Disorder. BioMed Research International،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-1027625
Modern Language Association (MLA)
Driban, Jeffrey B.…[et al.]. Joint Inflammation and Early Degeneration Induced by High-Force Reaching Are Attenuated by Ibuprofen in an Animal Model of Work-Related Musculoskeletal Disorder. BioMed Research International No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-1027625
American Medical Association (AMA)
Driban, Jeffrey B.& Barr, Ann E.& Amin, Mamta& Sitler, Michael R.& Barbe, Mary F.. Joint Inflammation and Early Degeneration Induced by High-Force Reaching Are Attenuated by Ibuprofen in an Animal Model of Work-Related Musculoskeletal Disorder. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-1027625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027625