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The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles
Joint Authors
Boncompagni, Simona
Franzini-Armstrong, Clara
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The spatial relationship between mitochondria and the membrane systems, more specifically the calcium release units (CRUs) of skeletal muscle, is of profound functional significance.
CRUs are the sites at which Ca2+ is released from the sarcoplasmic reticulum during muscle activation.
Close mitochondrion-CRU proximity allows the organelles to take up Ca2+ and thus stimulate aerobic metabolism.
Skeletal muscles of most mammals display an extensive, developmentally regulated, close mitochondrion-CRU association, fostered by tethering links between the organelles.
A comparative look at the vertebrate subphylum however shows that this specific association is only present in the higher vertebrates (mammals).
Muscles in all other vertebrates, even if capable of fast activity, rely on a less precise and more limited mitochondrion-CRU proximity, despite some tethering connections.
This is most evident in fish muscles.
Clustering of free subsarcolemmal mitochondria in proximity of capillaries is also more frequently achieved in mammalian than in other vertebrates.
American Psychological Association (APA)
Franzini-Armstrong, Clara& Boncompagni, Simona. 2011. The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027628
Modern Language Association (MLA)
Franzini-Armstrong, Clara& Boncompagni, Simona. The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-1027628
American Medical Association (AMA)
Franzini-Armstrong, Clara& Boncompagni, Simona. The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027628