Neural Degeneration in the Retina of the Streptozotocin-Induced Type 1 Diabetes Model
Joint Authors
Ban, Norimitsu
Ozawa, Yoko
Tsubota, Kazuo
Kurihara, Toshihide
Yuki, Kenya
Sasaki, Mariko
Kubota, Shunsuke
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetic retinopathy, a vision-threatening disease, has been regarded as a vascular disorder.
However, impaired oscillatory potentials (OPs) in the electroretinogram (ERG) and visual dysfunction are recorded before severe vascular lesions appear.
Here, we review the molecular mechanisms underlying the retinal neural degeneration observed in the streptozotocin-(STZ-) induced type 1 diabetes model.
The renin-angiotensin system (RAS) and reactive oxygen species (ROS) both cause OP impairment and reduced levels of synaptophysin, a synaptic vesicle protein for neurotransmitter release, most likely through excessive protein degradation by the ubiquitin-proteasome system.
ROS also decrease brain-derived neurotrophic factor (BDNF) and inner retinal neuronal cells.
The influence of both RAS and ROS on synaptophysin suggests that RAS-ROS crosstalk occurs in the diabetic retina.
Therefore, suppressors of RAS or ROS, such as angiotensin II type 1 receptor blockers or the antioxidant lutein, respectively, are potential candidates for neuroprotective and preventive therapies to improve the visual prognosis.
American Psychological Association (APA)
Ozawa, Yoko& Kurihara, Toshihide& Sasaki, Mariko& Ban, Norimitsu& Yuki, Kenya& Kubota, Shunsuke…[et al.]. 2011. Neural Degeneration in the Retina of the Streptozotocin-Induced Type 1 Diabetes Model. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-1027669
Modern Language Association (MLA)
Ozawa, Yoko…[et al.]. Neural Degeneration in the Retina of the Streptozotocin-Induced Type 1 Diabetes Model. Journal of Diabetes Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-1027669
American Medical Association (AMA)
Ozawa, Yoko& Kurihara, Toshihide& Sasaki, Mariko& Ban, Norimitsu& Yuki, Kenya& Kubota, Shunsuke…[et al.]. Neural Degeneration in the Retina of the Streptozotocin-Induced Type 1 Diabetes Model. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-1027669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027669