Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus

Joint Authors

Ishigaki, Yasushi
Kudo, Hirohito
Emi, Mitsuru
Ishii, Miho
Katagiri, Hideki
Hinokio, Yoshinori
Tsunoda, Uiko
Oka, Yoshitomo
Yamada, Tetsuya
Sato, Hidenori

Source

Journal of Diabetes Research

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-05-14

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases
Medicine

Abstract EN

A small portion of Type 2 diabetes mellitus (T2DM) is familial, but the majority occurs as sporadic disease.

Although causative genes are found in some rare forms, the genetic basis for sporadic T2DM is largely unknown.

We searched for a copy number abnormality in 100 early-onset Japanese T2DM patients (onset age <35 years) by whole-genome screening with a copy number variation BeadChip.

Within the 1.3-Mb subtelomeric region on chromosome 4p16.3, we found copy number losses in early-onset T2DM (13 of 100 T2DM versus one of 100 controls).

This region surrounds a genome gap, which is rich in multiple low copy repeats.

Subsequent region-targeted high-density custom-made oligonucleotide microarray experiments verified the copy number losses and delineated structural changes in the 1.3-Mb region.

The results suggested that copy number losses of the genes in the deleted region around the genome gap in 4p16.3 may play significant roles in the etiology of T2DM.

American Psychological Association (APA)

Kudo, Hirohito& Emi, Mitsuru& Ishigaki, Yasushi& Tsunoda, Uiko& Hinokio, Yoshinori& Ishii, Miho…[et al.]. 2011. Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027681

Modern Language Association (MLA)

Kudo, Hirohito…[et al.]. Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-1027681

American Medical Association (AMA)

Kudo, Hirohito& Emi, Mitsuru& Ishigaki, Yasushi& Tsunoda, Uiko& Hinokio, Yoshinori& Ishii, Miho…[et al.]. Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027681

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1027681