The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance
Joint Authors
Janikashvili, Nona
Larmonier, Nicolas
Katsanis, Emmanuel
Bonnotte, Bernard
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Tumor cells commonly escape from elimination by innate and adaptive immune responses using multiple strategies among which is the active suppression of effector immune cells.
Regulatory T lymphocytes (Treg) and tolerogenic dendritic cells play essential roles in the establishment and persistence of cancer-induced immunosuppression.
Differentiating dendritic cells (DCs) exposed to tumor-derived factors may be arrested at an immature stage becoming inept at initiating immune responses and may induce effector T-cell anergy or deletion.
These tolerogenic DCs, which accumulate in patients with different types of cancers, are also involved in the generation of Treg.
In turn, Treg that expand during tumor progression contribute to the immune tolerance of cancer by impeding DCs' ability to orchestrate immune responses and by directly inhibiting antitumoral T lymphocytes.
Herein we review these bidirectional communications between DCs and Treg as they relate to the promotion of cancer-induced tolerance.
American Psychological Association (APA)
Janikashvili, Nona& Bonnotte, Bernard& Katsanis, Emmanuel& Larmonier, Nicolas. 2011. The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-1027706
Modern Language Association (MLA)
Janikashvili, Nona…[et al.]. The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-1027706
American Medical Association (AMA)
Janikashvili, Nona& Bonnotte, Bernard& Katsanis, Emmanuel& Larmonier, Nicolas. The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-1027706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027706