The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis
Joint Authors
Wei, Xiao-Qing
Williams, David W.
Rogers, Helen
Lewis, Michael A. O.
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Candida albicans is an opportunistic fungal pathogen that normally exists as a harmless commensal in humans.
In instances where host debilitation occurs, Candida can cause a range of clinical infections, and whilst these are primarily superficial, effecting mucosal membranes, systemic infections can develop in severely immunocompromised individuals.
The mechanism of host immunity during commensal carriage of C.
albicans has been intensively studied.
In this paper, we present the most recent information concerning host recognition of C.
albicans leading to cytokine production and the subsequent T-cell responses generated in response to C.
albicans.
Particular focus is given to the role of the IL-12 cytokine family including IL-12, IL-23, IL-27, and IL-35, in host immunity to Candida.
CD4+ T-cells are considered crucial in the regulation of immunity and inflammation.
In this regard, the role of Th1/2, helper cells, together with the recently identified Th17 and Treg cells in candidosis will be discussed.
Understanding the detailed mechanisms that underlie host immunity to Candida not only will be of benefit in terms of the infections caused by this organism but could also be exploited in the development of therapeutic interventions for other diseases.
American Psychological Association (APA)
Wei, Xiao-Qing& Rogers, Helen& Lewis, Michael A. O.& Williams, David W.. 2010. The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027709
Modern Language Association (MLA)
Wei, Xiao-Qing…[et al.]. The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-1027709
American Medical Association (AMA)
Wei, Xiao-Qing& Rogers, Helen& Lewis, Michael A. O.& Williams, David W.. The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis. Journal of Immunology Research. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027709