Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART
Joint Authors
Worodria, William
Manabe, Yukari C.
Kestens, Luc
Mayanja-Kizza, Harriet
Namaganda, Jane
Kambugu, Andrew
Colebunders, Robert
Massinga-Loembe, Marguerite
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Commencement of antiretroviral treatment (ART) in severely immunosuppressed HIV-infected persons is associated with unmasking of subclinical disease.
The subset of patients that are diagnosed with tuberculosis (TB) disease while on ART have been classified as ART-associated TB.
Few studies have reported the incidence of ART-associated TB and unmasking TB-IRIS according to the International Network for the Study of HIV-Associated IRIS (INSHI) consensus definition.
To determine the incidence and predictors of ART-associated TB, we screened 219 patients commencing ART at the Infectious Diseases Clinic in Kampala, Uganda for TB by symptoms, sputum microscopy, and chest X-rays and followed them for one year.
Fourteen (6.4%) patients were diagnosed with TB during followup.
Eight (3.8%) patients had ART-associated TB (incidence rate of 4.3 per 100 person years); of these, three patients fulfilled INSHI criteria for unmasking TB-associated IRIS (incidence rate of 1.6 per 100 person years).
A body mass index of less than 18.5 kg/m2 BMI (HR 5.85 95% CI 1.24–27.46, P=.025) and a C-reactive protein greater than 5 mg/L (HR 8.23 95% CI 1.36–38.33, P=.020) were risk factors for ART-associated TB at multivariate analysis.
In conclusion, with systematic TB screening (including culture and chest X-ray), the incidence of ART-associated TB is relatively low in settings with high HIV and TB prevalence.
American Psychological Association (APA)
Worodria, William& Massinga-Loembe, Marguerite& Mayanja-Kizza, Harriet& Namaganda, Jane& Kambugu, Andrew& Manabe, Yukari C.…[et al.]. 2010. Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027710
Modern Language Association (MLA)
Worodria, William…[et al.]. Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-1027710
American Medical Association (AMA)
Worodria, William& Massinga-Loembe, Marguerite& Mayanja-Kizza, Harriet& Namaganda, Jane& Kambugu, Andrew& Manabe, Yukari C.…[et al.]. Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Journal of Immunology Research. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-1027710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027710