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The Immune Response to Tumors as a Tool toward Immunotherapy
Joint Authors
Pagliari, D.
Barone, C.
Cianci, R.
Landolfi, R.
Bagalà, C.
Casciano, F.
Pandolfi, Franco
Astone, A.
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Until recently cancer medical therapy was limited to chemotherapy that could not differentiate cancer cells from normal cells.
More recently with the remarkable mushroom of immunology, newer tools became available, resulting in the novel possibility to attack cancer with the specificity of the immune system.
Herein we will review some of the recent achievement of immunotherapy in such aggressive cancers as melanoma, prostatic cancer, colorectal carcinoma, and hematologic malignancies.
Immunotherapy of tumors has developed several techniques: immune cell transfer, vaccines, immunobiological molecules such as monoclonal antibodies that improve the immune responses to tumors.
This can be achieved by blocking pathways limiting the immune response, such as CTLA-4 or Tregs.
Immunotherapy may also use cytokines especially proinflammatory cytokines to enhance the activity of cytotoxic T cells (CTLs) derived from tumor infiltrating lymphocytes (TILs).
The role of newly discovered cytokines remains to be investigated.
Alternatively, an other mechanism consists in enhancing the expression of TAAs on tumor cells.
Finally, monoclonal antibodies may be used to target oncogenes.
American Psychological Association (APA)
Pandolfi, Franco& Cianci, R.& Pagliari, D.& Casciano, F.& Bagalà, C.& Astone, A.…[et al.]. 2011. The Immune Response to Tumors as a Tool toward Immunotherapy. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027712
Modern Language Association (MLA)
Pandolfi, Franco…[et al.]. The Immune Response to Tumors as a Tool toward Immunotherapy. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-1027712
American Medical Association (AMA)
Pandolfi, Franco& Cianci, R.& Pagliari, D.& Casciano, F.& Bagalà, C.& Astone, A.…[et al.]. The Immune Response to Tumors as a Tool toward Immunotherapy. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027712