Pregnancy Rates with Recombinant versus Urinary Human Chorionic Gonadotropin in In Vitro Fertilization: An Observational Study
Joint Authors
Zeke, József
Kanyó, Katalin
Zeke, Helga
Szilágyi, András
Konc, János
Cseh, Áron
Vásárhelyi, Barna
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Randomized clinical trials (RCTs) demonstrated the equal efficacy of urinary human chorionic gonadotropin (uhCG) and recombinant hCG (rhCG) products in in vitro fertilisation (IVF).
However, limitations inherent with RCTs necessitate the reinforcement of RCT results in real-life.
We retrospectively analyzed pregnancies after treatment with rhCG and uhCG products (n=391, and 96, resp.).
We found that laboratory-verified pregnancy occurred more frequently in rhCG patients than in those on uhCG (43% versus 30%, P=0.02).
The association remains significant (P=0.002) after its adjustment for clinical characteristics.
The prevalence of laboratory-verified pregnancies was higher with GnRH agonist use (P=0.012) and BMI under 30 kg/m2 (P=0.053) while decreased the age (P=0.014) and the number of previous failed attempts (P=0.08).
Similar (but not significant) trends were observed with rates of pregnancy filled the 24th week.
These results reinforce RCTs supporting the notion that rhCG is more efficient as uhCG during IVF.
American Psychological Association (APA)
Zeke, József& Kanyó, Katalin& Zeke, Helga& Cseh, Áron& Vásárhelyi, Barna& Szilágyi, András…[et al.]. 2011. Pregnancy Rates with Recombinant versus Urinary Human Chorionic Gonadotropin in In Vitro Fertilization: An Observational Study. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-1027874
Modern Language Association (MLA)
Zeke, József…[et al.]. Pregnancy Rates with Recombinant versus Urinary Human Chorionic Gonadotropin in In Vitro Fertilization: An Observational Study. The Scientific World Journal No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-1027874
American Medical Association (AMA)
Zeke, József& Kanyó, Katalin& Zeke, Helga& Cseh, Áron& Vásárhelyi, Barna& Szilágyi, András…[et al.]. Pregnancy Rates with Recombinant versus Urinary Human Chorionic Gonadotropin in In Vitro Fertilization: An Observational Study. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-1027874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027874