Quercetin Protects Primary Human Osteoblasts Exposed to Cigarette Smoke through Activation of the Antioxidative Enzymes HO-1 and SOD-1
Joint Authors
Braun, Karl F.
Freude, Thomas
Egaña, José T.
Schenck, Thilo L.
Buchholz, Arne
Schmitt, Andreas
Siebenlist, Sebastian
Schyschka, Lilianna
Neumaier, Markus
Stöckle, Ulrich
Nussler, Andreas K.
Ehnert, Sabrina
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Smokers frequently suffer from impaired fracture healing often due to poor bone quality and stability.
Cigarette smoking harms bone cells and their homeostasis by increased formation of reactive oxygen species (ROS).
The aim of this study was to investigate whether Quercetin, a naturally occurring antioxidant, can protect osteoblasts from the toxic effects of smoking.
Human osteoblasts exposed to cigarette smoke medium (CSM) rapidly produced ROS and their viability decreased concentration- and time-dependently.
Co-, pre- and postincubation with Quercetin dose-dependently improved their viability.
Quercetin increased the expression of the anti-oxidative enzymes heme-oxygenase- (HO-) 1 and superoxide-dismutase- (SOD-) 1.
Inhibiting HO-1 activity abolished the protective effect of Quercetin.
Our results demonstrate that CSM damages human osteoblasts by accumulation of ROS.
Quercetin can diminish this damage by scavenging the radicals and by upregulating the expression of HO-1 and SOD-1.
Thus, a dietary supplementation with Quercetin could improve bone matter, stability and even fracture healing in smokers.
American Psychological Association (APA)
Braun, Karl F.& Ehnert, Sabrina& Freude, Thomas& Egaña, José T.& Schenck, Thilo L.& Buchholz, Arne…[et al.]. 2011. Quercetin Protects Primary Human Osteoblasts Exposed to Cigarette Smoke through Activation of the Antioxidative Enzymes HO-1 and SOD-1. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027878
Modern Language Association (MLA)
Braun, Karl F.…[et al.]. Quercetin Protects Primary Human Osteoblasts Exposed to Cigarette Smoke through Activation of the Antioxidative Enzymes HO-1 and SOD-1. The Scientific World Journal No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-1027878
American Medical Association (AMA)
Braun, Karl F.& Ehnert, Sabrina& Freude, Thomas& Egaña, José T.& Schenck, Thilo L.& Buchholz, Arne…[et al.]. Quercetin Protects Primary Human Osteoblasts Exposed to Cigarette Smoke through Activation of the Antioxidative Enzymes HO-1 and SOD-1. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-1027878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027878