Comparative Effects of Triflusal, S-Adenosylmethionine, and Dextromethorphan over Intestinal IschemiaReperfusion Injury
Joint Authors
Camara-Lemarroy, Carlos Rodrigo
Cordero-Pérez, Paula
Alarcón-Galván, Gabriela
Torres-Gonzalez, Liliana
Muñoz-Espinosa, Linda E.
Fernandez-Garza, Nancy Esthela
Guzman-de la Garza, Francisco Javier
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Ischemia/reperfusion (I/R) is a condition that stimulates an intense inflammatory response.
No ideal treatment exists.
Triflusal is an antiplatelet salicylate derivative with anti-inflammatory effects.
S-adenosylmethionine is a metabolic precursor for glutathione, an endogenous antioxidant.
Dextromethorphan is a low-affinity N-methyl-D-aspartate receptor inhibitor.
There is evidence that these agents modulate some of the pathways involved in I/R physiopathology.
Intestinal I/R was induced in rats by clamping the superior mesenteric artery for 60 minutes, followed by 60 minutes of reperfusion.
Rats either received saline or the drugs studied.
At the end of the procedure, serum concentrations of tumor necrosis factor-alpha (TNF-alpha), malonaldehyde (MDA), and total antioxidant capacity (TAC) were determined and intestinal morphology analyzed.
I/R resulted in tissue damage, serum TNF-alpha and MDA elevations, and depletion of TAC.
All drugs showed tissue protection.
Only triflusal reduced TNF-alpha levels.
All drugs lowered MDA levels, but only triflusal and S-adenosylmethionine maintained the serum TAC.
American Psychological Association (APA)
Camara-Lemarroy, Carlos Rodrigo& Guzman-de la Garza, Francisco Javier& Cordero-Pérez, Paula& Alarcón-Galván, Gabriela& Torres-Gonzalez, Liliana& Muñoz-Espinosa, Linda E.…[et al.]. 2011. Comparative Effects of Triflusal, S-Adenosylmethionine, and Dextromethorphan over Intestinal IschemiaReperfusion Injury. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-1027882
Modern Language Association (MLA)
Camara-Lemarroy, Carlos Rodrigo…[et al.]. Comparative Effects of Triflusal, S-Adenosylmethionine, and Dextromethorphan over Intestinal IschemiaReperfusion Injury. The Scientific World Journal No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-1027882
American Medical Association (AMA)
Camara-Lemarroy, Carlos Rodrigo& Guzman-de la Garza, Francisco Javier& Cordero-Pérez, Paula& Alarcón-Galván, Gabriela& Torres-Gonzalez, Liliana& Muñoz-Espinosa, Linda E.…[et al.]. Comparative Effects of Triflusal, S-Adenosylmethionine, and Dextromethorphan over Intestinal IschemiaReperfusion Injury. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-1027882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027882