Cell-Oriented Modeling of Angiogenesis
Joint Authors
Guidolin, D.
Rebuffat, Piera
Albertin, Giovanna
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Due to its significant involvement in various physiological and pathological conditions, angiogenesis (the development of new blood vessels from an existing vasculature) represents an important area of the actual biological research and a field in which mathematical modeling proved particularly useful in supporting the experimental work.
In this paper, we focus on a specific modeling strategy, known as “cell-centered” approach.
This type of mathematical models work at a “mesoscopic scale,” assuming the cell as the natural level of abstraction for computational modeling of development.
They treat cells phenomenologically, considering their essential behaviors to study how tissue structure and organization emerge from the collective dynamics of multiple cells.
The main contributions of the cell-oriented approach to the study of the angiogenic process will be described.
From one side, they have generated “basic science understanding” about the process of capillary assembly during development, growth, and pathology.
On the other side, models were also developed supporting “applied biomedical research” for the purpose of identifying new therapeutic targets and clinically relevant approaches for either inhibiting or stimulating angiogenesis.
American Psychological Association (APA)
Guidolin, D.& Rebuffat, Piera& Albertin, Giovanna. 2011. Cell-Oriented Modeling of Angiogenesis. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-1027883
Modern Language Association (MLA)
Guidolin, D.…[et al.]. Cell-Oriented Modeling of Angiogenesis. The Scientific World Journal No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-1027883
American Medical Association (AMA)
Guidolin, D.& Rebuffat, Piera& Albertin, Giovanna. Cell-Oriented Modeling of Angiogenesis. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-1027883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027883