Embryonic Regulation of the Mouse Hematopoietic Niche
Joint Authors
Fraser, Stuart T.
Sugiyama, Daisuke
Inoue-Yokoo, Tomoko
Kulkeaw, Kasem
Mizuochi, Chiyo
Horio, Yuka
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Hematopoietic stem cells (HSCs) can differentiate into several types of hematopoietic cells (HCs) (such as erythrocytes, megakaryocytes, lymphocytes, neutrophils, or macrophages) and also undergo self-renewal to sustain hematopoiesis throughout an organism's lifetime.
HSCs are currently used clinically as transplantation therapy in regenerative medicine and are typically obtained from healthy donors or cord blood.
However, problems remain in HSC transplantation, such as shortage of cells, donor risks, rejection, and graft-versus-host disease (GVHD).
Thus, increased understanding of HSC regulation should enable us to improve HSC therapy and develop novel regenerative medicine techniques.
HSC regulation is governed by two types of activity: intrinsic regulation, programmed primarily by cell autonomous gene expression, and extrinsic factors, which originate from so-called “niche cells” surrounding HSCs.
Here, we focus on the latter and discuss HSC regulation with special emphasis on the role played by niche cells.
American Psychological Association (APA)
Sugiyama, Daisuke& Inoue-Yokoo, Tomoko& Fraser, Stuart T.& Kulkeaw, Kasem& Mizuochi, Chiyo& Horio, Yuka. 2011. Embryonic Regulation of the Mouse Hematopoietic Niche. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-1027884
Modern Language Association (MLA)
Sugiyama, Daisuke…[et al.]. Embryonic Regulation of the Mouse Hematopoietic Niche. The Scientific World Journal No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-1027884
American Medical Association (AMA)
Sugiyama, Daisuke& Inoue-Yokoo, Tomoko& Fraser, Stuart T.& Kulkeaw, Kasem& Mizuochi, Chiyo& Horio, Yuka. Embryonic Regulation of the Mouse Hematopoietic Niche. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-1027884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027884